Database & Annotations
Apropos is built on top of the Rat, Mouse and Human IPI datasets. IPI provides a comprehensive, non-redundant list of proteins for these three species and also provides extensive database cross references. The comprehensive cross references to the Rat Genome Database, Mouse Genome Database, Uniprot, Entrez Gene and others facilitates the annotation of each record with additional functional annotations.
 
Orthology Relationships
The sets of IPI records for the three species are tied together into ortholog groups using assignments from the MGD Orthology dataset.
 
Technical Details
Apropos is written using RubyOnRails and uses a MySQL database. Apache2 and Mongrel are combined to serve static and dynamic content.
Details
Database Statistics
Human IPI: 67k records
Rat IPI: 41k records
Mouse IPI: 52k records


Annotation Sources
Gene Ontology
Mammalian Phenotype Ontology
RGD Disease Ontology
KEGG Pathway database
RGD Pathway ontology


Related Links
apropos.mcw.edu
rgd.mcw.edu
informatics.jax.org
www.ncbi.nlm.nih.gov
proteomics.mcw.edu
uniprot.org
www.ebi.ac.uk/IPI/
www.geneontology.orghttp://rgd.mcw.eduhttp://rgd.mcw.eduhttp://informatics.jax.org/http://www.ncbi.nlm.nih.govhttp://proteomics.mcw.edu/http://uniprot.org/http://www.ebi.ac.uk/IPI/http://www.geneontology.orgshapeimage_2_link_0shapeimage_2_link_1shapeimage_2_link_2shapeimage_2_link_3shapeimage_2_link_4shapeimage_2_link_5shapeimage_2_link_6shapeimage_2_link_7